Abandoned by his parents as a child, Peter Parker, a.k.a. Spider-Man, was raised by his aunt and uncle. But Peter wants to understand who he is, so he can come to terms with his background. So he embarks on a quest to unravel his parents' disappearance, which soon leads him to Oscorp and Dr. Curt Connors' laboratory. Spider-Man soon comes face to face with the Lizard, Connors' alter ego. By deciding to use his powers, he will embrace his destiny.